Hi @paulmalyschko!
Sorry, I have not got email notice about your post somehow and I missed it.
As @nitroalex mentioned, libnitrokey at the moment supports only additional (that is, besides smartcard) features of the Pro and Storage devices - Password Safe, OTP and encrypted storage.
For Smartcard-related functionality OpenSC should be best with Nitrokey HSM. For Pro, Start and Storage better would probably be GPGME.
I will update libnitrokey's readme to make that clear.
Could I ask what were your initial plans? I could perhaps give you some more clues.